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<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Dears,<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:18.0pt'><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>Some CO-facts, you may know,
but I think the sight on that sharpens our feeling about that:<o:p></o:p></span></font></p>
<p class=MsoNormal style='margin-left:18.0pt'><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:18.0pt'><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>- In smokers about
10% to 15% of haemoglobin is occupied by CO. Due to that, there is a higher
hematokrit (more red blood-cells than normal). (already discussed)<o:p></o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>If someone lives on high
altitudes; this person gets adapted by getting more red blood-cells (already
known). If a smoker (living on sea-level ) travels to higher altitude (with his
higher hematokrit) and he/she has serious difficulties to breathe she/he will
stop to smoke or smokes less. By that the CO level falls at least within 24
hours, but her/his hematokrit-adaption due to CO still remains, and is needed
and already available for the lower O2 partial-pressure on high levels. -Mountaineers
need some days to adapt their hematokrit to higher altitude. They have to stay
in a high-level-camp for some days. <o:p></o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>I think, possibly do
smokers know/feel if they smoke too much in aspect of high level of CO and to
low adaption of the hematokrit. Certainly they have the same signs as light CO-poisoning
( and it is a poisoning in realty).<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>Coal-miners work under
higher CO-atmosphere condition within the mine. Their body responses even with adaption
to higher hematokrit. <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'> Mind, persons with low
hematokrit are serious poisoned by lower CO-concentrations, than persons with
normal hematokrit. <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>During pregnancy the baby
suffers from low oxygen-transport due to mothers blood-CO-rising by smoking. -Fetal
hemoglobin has not the 250-times bigger affinity to maternal-hemoglobin as CO. If
it was so the hemoglobin would not allow to untie the O2 for the tissue, where it
is needed.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>To decide if some
concentration of CO is dangerous, there are a lot of aspects which aggravate or
mitigate the situation and these facts can summarize or diminish the poisoning effect.
<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>Concentration in the
aspired air, duration of that aspiration, forced or not forced respiration ( e.g.
physical work forces respiration; rest lowers respiration), condition of the
hematokrit (adaption with high hematokrit in contrary loss of blood by bleeding
) adaptation or not of the body to low hematokrit (e.g. by chronical lack of haemoglobin
or sudden loss of blood. <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>It is very important to
be aware of such summarizing effects and which those are, to get a feeling of
the actual poisoning effect of CO for a real person under the conditions in the
circumstances of that real minute. It can be at the same time ignorable for one
person and deadly for another.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 face=Arial><span lang=EN-GB style='font-size:10.0pt;font-family:Arial'><span
style='mso-list:Ignore'>-<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></span></font><![endif]><font size=2 face=Arial><span
lang=EN-GB style='font-size:10.0pt;font-family:Arial'>By googling you will get
a lot of information all about that. In German there is, but I am sure in
English as well. It is worth to do so, to get a more realistic approach to CO
and its danger. At least the mind is sharpened to be aware of some unnoticed
dangerous small circumstances, making a big difference in poisoning effect.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><span class=normal><b><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;font-weight:bold'>CO-average in expired air:<o:p></o:p></span></font></b></span></p>
<p class=MsoNormal><span class=normal><b><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;font-weight:bold'> (Source: <a
href="http://www.nichtraucher-wiesbaden.de/informationen/messgeraete/kohlenmonoxidmegeraet.html">http://www.nichtraucher-wiesbaden.de/informationen/messgeraete/kohlenmonoxidmegeraet.html</a>
)<o:p></o:p></span></font></b></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'>1 bis 3 ppm not-smokers</span></font></span><span
lang=EN-GB><br>
<span class=normal>4 bis 9 ppm passive-smokers <o:p></o:p></span></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'>6 bis 20 ppm few-smoker <o:p></o:p></span></font></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'>21 bis 100 ppm much-smoker <o:p></o:p></span></font></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'><o:p> </o:p></span></font></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'>Reason for CO-synthesis in body:<o:p></o:p></span></font></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'>(<a
href="http://www.bgbau.de/d/co_vergiftung/service/_PDF_PPS/kaefferlein1.pdf">http://www.bgbau.de/d/co_vergiftung/service/_PDF_PPS/kaefferlein1.pdf</a>
)<o:p></o:p></span></font></span></p>
<p class=MsoNormal><span class=normal><font size=3 face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt'> ( main-reason: decomposing of haemoglobin)<o:p></o:p></span></font></span></p>
<p class=MsoNormal style='text-autospace:none'><font size=2 face=Helvetica><span
style='font-size:10.0pt;font-family:Helvetica'>Die wichtigste endogene Quelle
(endogen heißt dabei, nicht von außen in den Körper<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=2 face=Helvetica><span
style='font-size:10.0pt;font-family:Helvetica'>getragen, sondern im Körper
selbst generiert), ist der Hämoglobinabbau, d.h. wenn der rote Blutfarbstoff<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Helvetica><span style='font-size:10.0pt;
font-family:Helvetica'>abgebaut wird und dabei CO im Körper entsteht.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Helvetica><span style='font-size:10.0pt;
font-family:Helvetica'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Helvetica><span lang=EN-GB
style='font-size:10.0pt;font-family:Helvetica'>Regards<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Helvetica><span lang=EN-GB
style='font-size:10.0pt;font-family:Helvetica'>Martin<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Helvetica><span lang=EN-GB
style='font-size:10.0pt;font-family:Helvetica'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
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