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<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Building intelligent power grids ( I will send attachments upon request)</span></font></p>
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<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I worked developing training scenarios on an EMS/SCADA for Public Service Company of NM (PNM).</span></font></p>
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<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I used PI Historian to predict wind farm load fluctuations.
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<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.pnm.com/systems/nmwec.htm" target="_blank">http://www.pnm.com/systems/nmwec.htm</a></span></font></p>
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<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Wind Power Grids in NM:</span></font></p>
<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://scratch.mit.edu/projects/GeneMachine/733654" target="_blank">http://scratch.mit.edu/projects/GeneMachine/733654</a></span></font></p>
<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p></span></font>I built genetic algorithms to predict Human Genome contig maps at Los Alamos National Laboratory Human Genome Project. I created a Mycin like AI that used expertise from many users to predict the human genome.
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<p>Recently my son and I used a similar approach to build an Exoplanet modeling tool using Kepler data. It predicts simple patterns in planet systems using a java graphics tool called processing (<a href="http://processing.org" target="_blank">http://processing.org</a>).</p>
<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.challenge.nm.org/archive/10-11/finalreports/35.pdf" target="_blank">http://www.challenge.nm.org/archive/10-11/finalreports/35.pdf</a></span></font></p>
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<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Recent work by IBM Watson using Hadoop and Map/Reduce will be applied to medical diagnostics using Mycin as the model.</span></font></p>
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<p><font color="navy" face="Arial"><span style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Oncotype-DX has revolutionized cancer treatment by collecting tumor samples and characterizing cancer DNA. It allows some women to avoid chemotherapy.</span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.genomichealth.com/" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.genomichealth.com/</span></font></a></span></font></p>
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<p><font color="navy" face="Arial"><span style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><a href="http://gcat.davidson.edu/Pirelli/index.htm" target="_blank">http://gcat.davidson.edu/Pirelli/index.htm</a></span></font></p>
<p><font color="navy" face="Arial"><span style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">IBM has announced it will now use Watson at Columbia University and University of Maryland to resurrect MYCIN.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">MYCIN was an automated blood diagnostic expert system which combined blood diagnostics from many doctors.
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">MYCIN failed because diagnostics took weeks in the 1970’s. Today a similar program can be refined daily to increase accuracy.</span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">http://www.time.com/time/business/article/0,8599,2049826,00.html</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://en.wikipedia.org/wiki/Mycin" target="_blank"><font color="black"><span style="COLOR: windowtext">http://en.wikipedia.org/wiki/Mycin</span></font></a></span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">How to build Watson from free software:</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">https://www.ibm.com/developerworks/mydeveloperworks/blogs/InsideSystemStorage/entry/ibm_watson_how_to_build_your_own_watson_jr_in_your_basement7?lang=en</span></font></p>
<p class="MsoNormal"><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">New breast cancer tumor diagnostics create an opportunity for IBM to provide the genome community with Watson as a solution to tumor diagnostics data. The Oncotype DX
test of Genomic Health (Redwood City, CA) was approved by Medicare 6/2010.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.genomichealth.com/" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.genomichealth.com/</span></font></a></span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">This test prescribes specific treatments for women with breast cancer based on their tumor markers.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">It is a revolution in breast cancer. Colon and lung cancer may also use a similar test soon.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">These tests become more accurate as data is entered into treatment databases.</span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">A new DNA chip developed by Mass. Genl. Hospital and Johnson and Johnson may predict cancer decades before tumors grow.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could IBM Watson be used to cross analyze blood samples for this new test?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">http://www.technologytransfertactics.com/content/2011/01/05/mass-general-partners-with-jj-to-commercialize-cancer-test/</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a title="blocked::http://nextbigfuture.com/2011/01/microfluidics-chip-that-captures-rare.html" href="http://nextbigfuture.com/2011/01/microfluidics-chip-that-captures-rare.html" target="_blank"><font color="black"><span style="COLOR: windowtext">http://nextbigfuture.com/2011/01/microfluidics-chip-that-captures-rare.html</span></font></a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a title="blocked::http://www.technologyreview.com/blog/editors/26218/" href="http://www.technologyreview.com/blog/editors/26218/" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.technologyreview.com/blog/editors/26218/</span></font></a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a title="blocked::http://www.technologyreview.com/biomedicine/19969/" href="http://www.technologyreview.com/biomedicine/19969/" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.technologyreview.com/biomedicine/19969/</span></font></a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.ncbi.nlm.nih.gov/pubmed/20930119" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.ncbi.nlm.nih.gov/pubmed/20930119</span></font></a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.aacr.org/home/public--media/stand-up-to-cancer/su2c-dream-teams/bioengineering-and-clinical-applications-of-circulating-tumor-cell-chip.aspx" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.aacr.org/home/public--media/stand-up-to-cancer/su2c-dream-teams/bioengineering-and-clinical-applications-of-circulating-tumor-cell-chip.aspx</span></font></a></span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">UIMA is the brains of Watson. It is an automated annotation system.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">http://uima.apache.org/</span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">UIMA could be invaluable in tracking research in cancer molecular biology.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Cancer research is a rapidly evolving field with many research projects.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Genetically cancer is a context switching machine that is constantly changing.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">One treatment is usually followed by another as the cancer changes.
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Treatments are growing exponentially and can be matched to genetic markers.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">There needs to be a group of cancer UIMA systems updating each other similar to the Human Genome databases and Genbank.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.ncbi.nlm.nih.gov/genbank/" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.ncbi.nlm.nih.gov/genbank/</span></font></a></span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Genbank was annotated by researchers by hand. UIMA may allow the automated annotation of genomic data.</span></font></p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">A data classification system needs to involve today’s microarrays with tomorrow’s advances in bio chips.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://uima.apache.org/" target="_blank"><font color="black"><span style="COLOR: windowtext">http://uima.apache.org/</span></font></a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://abhishek-tiwari.com/2009/04/3r-systems-reading-reasoning-and.html" target="_blank"><font color="black"><span style="COLOR: windowtext">http://abhishek-tiwari.com/2009/04/3r-systems-reading-reasoning-and.html</span></font></a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">http://www.youtube.com/watch?v=jAegU3aZbWI</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">http://www.computer.org/portal/web/csdl/doi/10.1109/ISM.Workshops.2007.24</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://www.orbitproject.org/resource/colorectal-cancer-uima-annotators-prostate-cancer-uima-annotators" target="_blank"><font color="black"><span style="COLOR: windowtext">http://www.orbitproject.org/resource/colorectal-cancer-uima-annotators-prostate-cancer-uima-annotators</span></font></a></span></font></p>
<p class="MsoNormal"><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could MutationFinder cross correlate tumor markers to treatments similar to Oncotype-DX?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://mutationfinder.sourceforge.net/Caporaso2007a.pdf" target="_blank">http://mutationfinder.sourceforge.net/Caporaso2007a.pdf</a></span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I have created a powerpoint on Comparative Genomics in Cancer.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">It is 3 MB in size and I will send if you are interested. It shows how to use processing to build genetic network maps of cancer.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Power grids act deterministically most of the time.
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Breast cancer is also beginning to become predictable with Oncotype DX.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">By building multiple network responses the grid and cancer may become more predictable over time.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could power grid modeling and medical diagnostics have parallels?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Gene networks and electric networks can now be modeled using processing.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">See attached PNM Power Grid Model.doc</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could algorithms for both seek irregularities and approach solutions similarly?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Smart grids will be challenged by new technology and will need to adapt.</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Example:</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">If Ecat could be attached to a Thermo Electric Generator a constant flow of electricity produced locally could decentralize the grid.
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: black; FONT-SIZE: 10pt">Ecat
Scratch Cartoon </span></span></font></p>
<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: black; FONT-SIZE: 10pt"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><a href="http://scratch.mit.edu/projects/GeneMachine/1791470" target="_blank">http://scratch.mit.edu/projects/GeneMachine/1791470</a></span></span></span></font></p>
<p><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: black; FONT-SIZE: 10pt"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></span></span></font> </p>
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<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could local EMS/SCADA take over for public utility and coop EMS/SCADA?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could cloud computing reconfigure the national grid to adapt using Hadoop?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Would fluctuation of load be balanced by local production?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Could a processing model for local zones of control work?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Would simulations show a model that stabilizes without external transmission?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Would external transmission become a cost customers would tolerate?</span></font></p>
<p class="MsoNormal"><font face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"></span></font> </p>
<p class="MsoNormal"></span></font><font size="2" face="Arial"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><br>
Henry Brown<br>
<a href="mailto:hbrown@sisna.com" target="_blank">hbrown@sisna.com</a><br>
505 795-3680</span></font></p>
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