[Stoves] CO- and Oxygen-affinity to haemoglobine

[Boll, Martin Dr.]

Dears,

 

Some CO-facts, you may know, but I think the sight on that sharpens our
feeling about that:

 

-     In smokers about 10% to 15% of haemoglobin is occupied by CO. Due to
that, there is a higher hematokrit  (more red blood-cells than normal).
(already discussed)

-          If someone lives on high altitudes; this person gets adapted by
getting more red blood-cells (already known). If a smoker (living on
sea-level ) travels to higher altitude (with his higher hematokrit) and
he/she has serious difficulties to breathe she/he will stop to smoke or
smokes less. By that the CO level falls at least within 24 hours, but
her/his hematokrit-adaption due to CO still remains, and is needed and
already available for the lower O2 partial-pressure on high levels.
-Mountaineers need some days to adapt their hematokrit to higher altitude.
They have to stay in a high-level-camp for some days. 

-          I think, possibly do smokers know/feel if they smoke too much in
aspect of high level of CO and to low adaption of the hematokrit. Certainly
they have the same signs as light CO-poisoning ( and it is a poisoning in
realty).

 

-          Coal-miners work under higher CO-atmosphere condition within the
mine. Their body responses even with adaption to higher hematokrit. 

 

-           Mind, persons with low hematokrit are serious poisoned by lower
CO-concentrations, than persons with normal hematokrit. 

 

-          During pregnancy the baby suffers from low oxygen-transport due
to mothers blood-CO-rising by smoking. -Fetal hemoglobin has not the
250-times bigger affinity to maternal-hemoglobin as CO. If it was so the
hemoglobin would not allow to untie the O2 for the tissue, where it is
needed.

 

-          To decide if some concentration of CO is dangerous, there are a
lot of aspects which aggravate or mitigate the situation and these facts can
summarize or diminish the poisoning effect.  

 

-          Concentration in the aspired air, duration of that aspiration,
forced or not forced respiration ( e.g. physical work forces respiration;
rest lowers respiration), condition of the hematokrit (adaption with high
hematokrit in contrary loss of blood by bleeding ) adaptation or not of the
body to low hematokrit (e.g. by chronical lack of haemoglobin or sudden loss
of blood. 

 

-          It is very important to be aware of such summarizing effects and
which those are, to get a feeling of the actual poisoning effect of CO for a
real person under the conditions in the circumstances of that real minute.
It can be at the same time ignorable for one person and deadly for another.

 

-          By googling you will get a lot of information all about that. In
German there is, but I am sure in English as well. It is worth to do so, to
get a more realistic approach to CO and its danger. At least the mind is
sharpened to be aware of some unnoticed dangerous small circumstances,
making a big difference in poisoning effect.

 

 

CO-average in expired air:

 (Source:
http://www.nichtraucher-wiesbaden.de/informationen/messgeraete/kohlenmonoxid
megeraet.html )

1 bis 3 ppm not-smokers
4 bis 9 ppm passive-smokers 

6 bis 20 ppm few-smoker 

21 bis 100 ppm much-smoker 

 

Reason for CO-synthesis in body:

(http://www.bgbau.de/d/co_vergiftung/service/_PDF_PPS/kaefferlein1.pdf )

 ( main-reason: decomposing of haemoglobin)

Die wichtigste endogene Quelle (endogen heißt dabei, nicht von außen in den
Körper

getragen, sondern im Körper selbst generiert), ist der Hämoglobinabbau, d.h.
wenn der rote Blutfarbstoff

abgebaut wird und dabei CO im Körper entsteht.

 

Regards

Martin

 

 

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